Robert de Niro/Martin Scorsese
Leonardo diCaprio/Martin Scorsese
John Wayne/John Ford
James Stewart/Anthony Mann
Samuel L. Jackson/Quentin Tarantino
Brad Pitt/David Fincher
Frances McDormand/Coen Brothers
Philip Seymour Hoffman/Paul Thomas Anderson
Clint Eastwood/Sergio Leone
James Stewart/Alfred Hitchcock
Tom Hanks/Steven Spielberg
John Wayne/Howard Hawks
Clint Eastwood/Don Siegel
Jonathan Pryce/Terry Gilliam
Michael Caine/Christopher Nolan
Guy Pearce/John Hillcoat
Jason Statham/Guy Ritchie
Russell Crowe/Ridley Scott
Ron Perlman/Guillermo del Toro
Kurt Russell/John Carpenter
Johnny Depp/Tim Burton
Johnny Depp/Gore Verbinski
Max von Sydow/Ingmar Bergman
Randolph Scott/Budd Boetticher
Ewan McGregor/Danny Boyle
Kirsten Dunst/Sofia Coppola
Klaus Kinski/Werner Herzog
Will Ferrell/Adam McKay
John Wayne/Andrew V. McLaglen
Michael Fassbender/Steve McQueen
Burt Reynolds/Hal Needham
Warren Oates/Sam Peckinpah
and more, but I ran out of characters...do you recognise the remaining pairings?