Many actors have had the misfortune in staring only in one season or one critically-acclaimed show. Others are fortunate and have gone on to star in multiple successful shows. For those listed below, they have to play a leading role, the shows lasting more than two seasons, and has played in more than three successful shows. I did not include voice acting. They're in no order. I've listed a few examples.
1. Ted Danson: Cheers - 270, Becker - 120, CSI - 84, The Good Place - 50, Damages - 23
2. Betty White: Life with Elizabeth - 39, The Mary Tyler Moore Show - 45, The Golden girls - 177, Hot in Cleveland - 124
3. Raven Symone: The Cosby Show - 64, Hangin' with Mr. Cooper - 79, That's So Raven - 100, Ravens Home - 81
4. David Boreanaz: Angel - 111, Bones - 245, Seal Team - 89
5. Tony Shalhoub: Wings - 144, Monk - 125, the Marvelous Mrs. Maisel - ongoing