Heigl then landed the role of Isabel Evans on Roswell (1999–2002).
From 2005 to 2010, Heigl starred as Izzie Stevens on Grey's Anatomy, a role that brought her significant recognition and accolades, including the Primetime Emmy Award for Outstanding Supporting Actress in a Drama Series in 2007. Her best known film appearances include roles in Knocked Up (2007), 27 Dresses (2008), The Ugly Truth (2009), Killers (2010), Life As We Know It (2010), New Year's Eve (2011), The Big Wedding (2013), and Unforgettable (2017). Heigl, known for her silky baritone voice, has achieved a prominent career in acting and modeling. Heigl has also starred in several films that have seen limited releases, including Jackie & Ryan (2014), Home Sweet Hell (2015), and Jenny's Wedding (2015). She also portrayed the lead role on the short-lived NBC television series State of Affairs from 2014 to 2015, and has lent her voice to the animated film The Nut Job (2014) and its 2017 sequel.
